On-the-Spot® Acne Treatment
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On-the-Spot® Acne Treatment
0.75 oz
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Rated 3.6 out of 5 by 109 reviewers.
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On-the-Spot® Acne Treatment is a spot acne treatment that provides maximum-strength results without drying out your face. It goes deep down in pores to kill the acne bacteria that cause pimples and helps stop new ones from forming.

Some medicated spot treatments contain high doses of Benzoyl Peroxide that can irritate skin, causing redness and dryness that can make acne worse. On-the-Spot® Acne Treatment contains just 2.5% Benzoyl Peroxide, yet it provides the same maximum level of effectiveness with 70% less irritation.

Fight acne and get maximum-strength results with an acne spot treatment that won't dry out your face.
  • Oil-free
  • Non-comedogenic (won't clog pores)
  • 2.5% Benzoyl Peroxide
Rated 1.0 out of 5.0 by Awful Breakout I have loved other Neutrogena acne products and I wanted to love this one, but it broke me out horribly. After using it I had large patches of scaly skin and acne around the area for days. I would caution anyone with dry or sensitive skin to be very cautious with this product. Dec 9, 2014
Rated 1.0 out of 5.0 by Disappointed This was one of the first spot treatments I bought for my mild acne (blackheads and whiteheads as a result of puberty, sigh). It didn't do anything for my acne, so I moved on to other products. A few months later, I decided to give it another try. It was the only change in my routine, and a few days later, my face became irritated, rough, and itchy. I stopped using immediately and now my face is ok again...but still acne-prone. A waste of money and a disappointing product...do not purchase. Nov 29, 2014
Rated 5.0 out of 5.0 by cant find any more of it! HELP!! I used just one tube of it and my 10years Acne and blackheads started to clear out for the very first time!! I have been battling with Pimples and Acne for the past 10years since I was 16, now am 26.. After the second tube, my skin was visibly clear FOR THE VERY FIRST TIME for a long as I can ever remember, I was able to go out without make up on to conceal the blackheads, something I can remember the last time I stepped out without the need to conceal my horrifying blackheads and Acne. However after the second tube, I went back to get the tube again from my supplier and thy had ran out of It. THEN MY PIMPLE STARTED COMING BACK after all efforts to get it have proved futile as no other stores seems to have it. Please Help! Can I order he and you ship it to me in Nigeria Africa? Nov 25, 2014
Rated 5.0 out of 5.0 by Cleared up most of my acne! I really love this product. I don't use it as a spot treatment, instead covering all my problem areas every night. It has really helped my existing acne and helps prevent anything new. It is quiet drying, but I think my skin is used to it now. Great product! Nov 23, 2014
Rated 2.0 out of 5.0 by Scary After using this product my skin has dried out and started peeling. Another time it made my skin red and puffy. Kind of scary. It does get rid of acne though after the peeling. Nov 14, 2014
Rated 5.0 out of 5.0 by Gets Rid of Cystic Acne In a Flash I wouldn't necessarily say I have cystic acne for I don't have horrible outbreaks or anything, but I do definitely get a few cysts around my nose and forehead from time to time. It sucks so bad to have to endure a social situation with a very unsightly red bumb on my face. I feel insecure when I notice people staring while I speak to them. As soon as I notice a little bump begin to appear, I gently break the opening of the pour (consult your doctor to learn how to do that properly and cleanly) and lather this stuff on. Instead of the cysts lasting a week to a month or more, they begin to get smaller in just a few days. I have never tried another product that has worked as well besides the nasty smelling stuff the doctor prescribes you. It's well worth the money and I'm extremely satisfied with it! Makes my life a lot easier. Oct 28, 2014
Rated 1.0 out of 5.0 Disappointing product I do not have an acne problem, but occasionally, pimples will appear on my face. I decided to give this treatment a try because my pimples were not going away after around 1-2 weeks, even after I used the typical products that work for me. Unfortunately after using this product, my pimples and the area around them became more red, swollen and sore. Aug 23, 2014
Rated 2.0 out of 5.0 by Works well on acne but skin has become rough. I had just one application of the cream on the cheeks where there is some acne. The skin lost its luster and is not soft as ever. I stopped using the cream immediately but the effect is still there. Aug 22, 2014
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Wash your face with gentle cleanser and pat dry. Apply directly on pimples. Apply once a day initially, then two or three times daily. If irritation or excess dryness occurs, reduce application to once a day.
While Neutrogena strives to keep ingredient lists on this website as accurate as possible, we cannot guarantee that these lists are complete, reliable, up-to-date, and error-free. Please refer to the ingredients list on the product packaging for the most accurate list of ingredients.

Active Ingredients:
Benzoyl Peroxide 2.5%

Inactive Ingredients:
Water, Bentonite, Caprylic/Capric Triglyceride, Glycerin, Emulsifying Wax NF, Polysorbate 20, Glyceryl Laurate, Cetyl Dimethicone, Magnesium Aluminum Silicate, Xanthan Gum, Sodium Citrate, Disodium EDTA, Citric Acid, Methylparaben, Propylparaben

Warning: For external use only. When using this product skin irritation and dryness is more likely to occur if you use another topical medication at the same time. If irritation occurs, only use one topical medication at a time. Do not use if you have very sensitive skin or are sensitive to benzoyl peroxide. When using this product, avoid unnecessary sun exposure and use a sunscreen. Avoid contact with the eyes, lips and mouth. Avoid contact with hair or dyed fabrics, which may be bleached by this product. Skin irritation may occur, characterized by redness, burning, itching, peeling or possibly swelling. Irritation may be reduced by using the product less frequently or in a lower concentration. Stop use and ask a doctor if irritation becomes severe. Keep out of reach of children. If swallowed, get medical help or contact a poison control center right away.
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