On-the-Spot® Acne Treatment
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On-the-Spot® Acne Treatment
0.75 oz
Rated 3.6 out of 5 by 116 reviewers.
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On-the-Spot® Acne Treatment is a spot acne treatment that provides maximum-strength results without drying out your face. It goes deep down in pores to kill the acne bacteria that cause pimples and helps stop new ones from forming.

Some medicated spot treatments contain high doses of Benzoyl Peroxide that can irritate skin, causing redness and dryness that can make acne worse. On-the-Spot® Acne Treatment contains just 2.5% Benzoyl Peroxide, yet it provides the same maximum level of effectiveness with 70% less irritation.

Fight acne and get maximum-strength results with an acne spot treatment that won't dry out your face.
  • Oil-free
  • Non-comedogenic (won't clog pores)
  • 2.5% Benzoyl Peroxide

Item #: 070501017906
Rated 5.0 out of 5.0 by So fast! I've been having issues with blackheads and pimples on my chin for the last 5 or 6 years (I'm 19 so guess why) and it always looks like it could break out at any time.The first night I used it I put this product on before I went to bed (put face moisturizer over it after it had soaked in so it wouldn't dry out overnight) and In the morning my skin was beautiful! I still had a few black heads, but all the beginning pimples are gone and the bigger ones are smaller and less noticeable! I love this product and am probably gonna use it forever. Nov 13, 2015
Rated 1.0 out of 5.0 Thought it would get rid of my acne but no... I was debating over this and some other spot treatment but after seeing some good reviews I decided to go with this one. I'm not one to usually write reviews but this spot treatment did not work at all for me. I put some on at night and went to bed and when I woke up in the morning I had really dark/red spots on the spots I put the cream on. I freaked out seeing the spots but what made things worse was that my face started cracking and the cream dried my face out. It's been a few days and my face still has red spots. I was hoping to like this product but it made my skin even worse. Neutrogena products usually work for me but this one I really do regret purchasing. Oct 30, 2015
Rated 5.0 out of 5.0 by Best ever! Beats out Proactiv! I know every bodies skin is different...... For me: I've used Proactiv for about 15+ years. As the one product of theirs that I was using is getting harder & harder for me to find. I decided to venture out & search for something new & something easier to obtain. I got this because it has the same amount of active ingredient as what I was using with Proactiv. OMG! It actually works better for me!!!! Nothing has ever worked better than Proactiv, but this does!!!! (I use On-The-Spot all over my face in the morning & Rapid Clear just on my T-zone at night.) Jun 13, 2015
Rated 5.0 out of 5.0 by Life Saver! I've always struggled with the worst acne imaginable and could never find anything that worked until I started trying this! It is a lifesaver and I am so happy and can feel my self confidence flying with the results! May 24, 2015
Rated 5.0 out of 5.0 by Miracle! I used this product on a big pimple I had on my nose before going to bed. The next morning, the pimple was gone with no scar or anything! For me, this product generally works better in the night time, because each time I use it in the day time, there is no progress made. But overall, it's a life saver!! Mar 3, 2015
Rated 5.0 out of 5.0 by WOW I have some chin acne that I want to get cleared up. I bought this product on Friday and started using it immediately one to three times a day like the directions say. Today is Sunday, and I am already seeing fast results. This product is amazing and is worth every penny I paid. Neutrogena continues to be number one in skin care products! The best! Dec 21, 2014
Rated 4.0 out of 5.0 by Wish there was a 5% formula I suddenly had a small cluster of pimples develop on my chin and mouth areas a few months back. It seemed like I tried everything under the sun besides actually seeing a dermatologist. I finally stopped most products and continued to use my mild face wash. This definitely helped but I still needed something more. I tried this and it really has helped that area so much. I am still dealing with a few pimples around my mouth but they are nothing like they used to be. I use a small amount morning and night and pile on the moisturizer and I find I don't get dry at all. I will continue to use this product but my only wish is that it came in a 5% formula as well. It is very gentle but I feel on stubborn pimples it may be just a little too weak even if used daily. It's almost like it's right on the cusp of being great! Dec 18, 2014
Rated 1.0 out of 5.0 by Awful Breakout I have loved other Neutrogena acne products and I wanted to love this one, but it broke me out horribly. After using it I had large patches of scaly skin and acne around the area for days. I would caution anyone with dry or sensitive skin to be very cautious with this product. Dec 9, 2014
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Wash your face with gentle cleanser and pat dry. Apply directly on pimples. Apply once a day initially, then two or three times daily. If irritation or excess dryness occurs, reduce application to once a day.
While Neutrogena strives to keep ingredient lists on this website as accurate as possible, we cannot guarantee that these lists are complete, reliable, up-to-date, and error-free. Please refer to the ingredients list on the product packaging for the most accurate list of ingredients.

Active Ingredients:
Benzoyl Peroxide 2.5%

Inactive Ingredients:
Water, Bentonite, Caprylic/Capric Triglyceride, Glycerin, Emulsifying Wax NF, Polysorbate 20, Glyceryl Laurate, Cetyl Dimethicone, Magnesium Aluminum Silicate, Xanthan Gum, Sodium Citrate, Disodium EDTA, Citric Acid, Methylparaben, Propylparaben

Warning: For external use only. When using this product skin irritation and dryness is more likely to occur if you use another topical medication at the same time. If irritation occurs, only use one topical medication at a time. Do not use if you have very sensitive skin or are sensitive to benzoyl peroxide. When using this product, avoid unnecessary sun exposure and use a sunscreen. Avoid contact with the eyes, lips and mouth. Avoid contact with hair or dyed fabrics, which may be bleached by this product. Skin irritation may occur, characterized by redness, burning, itching, peeling or possibly swelling. Irritation may be reduced by using the product less frequently or in a lower concentration. Stop use and ask a doctor if irritation becomes severe. Keep out of reach of children. If swallowed, get medical help or contact a poison control center right away.
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